To investigate such cell–cell crosstalk, the facts have established that communication between stromal stem cells with the breast carcinoma cells mediated by Twist1 protein player leads to aberrant expression of miRNAs, specifically led by miRNA-199a, which ultimately landed in repression of Forkhead box protein P2 (FOXP2) transcription factor, that may be responsible to encourage breast cancer survival and progression (93). The gene discussed is FOXP2; the disease is breast carcinoma.