SLC8A1 and hydrops fetalis: The level of miR-1 was downregulated in a chronic rat HF model and its expression was restored to normal levels during reverse remodeling by sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) gene therapy through an Akt/FoxO3A-dependent pathway, which was also associated with normalized sodium-calcium exchanger 1 (NCX1, functional target of miR-1) expression and significantly improved cardiac function [79].