Circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly upregulated in response to hypertension-induced HF, whereas this effect was blunted in response to treatment with anti-miR-208a as well as an ACE inhibitor and prevented progression of hypertension-induced heart HF [58]. The gene discussed is ACE; the disease is hypertensive disorder.