Melanoma studies have revealed a myriad of GPCR and mutations found in GPCRs that may be involved in melanoma progression including, melanocortin type 1 receptor, endothelin receptor, metabotropic glutamate receptor-1, 3, and 8, platelet-activating factor receptor, and Wnt/frizzled receptor among others (Lee et al., 2008; Prickett et al., 2011). This evidence concerns the gene GRM1 and melanoma.