When disease stage discriminating ability of IFN-γ, IL-17, and IL-4 were tested with a more homogeneous LTBI group, namely the RA group, the combined analysis of IFN-γ, IL-17, and IL-4 or IFN-γ and IL-4 resulted in 64% sensitivity (p < 0.05) with 100% specificity. This evidence concerns the gene IL4 and rheumatoid arthritis.