CD8A and infection: The data thus far gave the unequivocal message that absence of IDE-specific CD8+ T cells during reconstitution after HCT differs fundamentally from a pan-CD8+ T-cell depletion in that the recipients still control the infection and survive, whereas the pan-depletion led to lethal multiple-organ CMV disease in 100% of the HCT recipients (see the accompanying Review article in this issue of Frontiers in Immunology).