Notably, although immunodominance could be defined at the level of TCR-pMHC-I interaction driving T-cell expansion, we did not observe notable and reproducible expansion of CD8+ T cells specific for defined non-IDEs in the absence of IDEs upon infection of mice with mutant virus mCMV-Δ4IDE during either acute or latent infection in the spleen [(57) and this report, respectively]. This evidence concerns the gene CD8A and disease arising from reactivation of latent virus.