Here, we have expanded our previous work in the murine model by addressing the question if IDE-specificity of CD8+ T cells is essential for controlling CMV infection in the specific context of immunoreconstitution after HCT when T-cell lymphopoiesis, thymic selection, and priming take place under conditions imposed by the infection, including an altered cytokine-chemokine milieu. The gene discussed is CD8A; the disease is infection.