Notably, although immunodominance could be defined at the level of TCR-pMHC-I interaction driving T-cell expansion, we did not observe notable and reproducible expansion of CD8+ T cells specific for defined non-IDEs in the absence of IDEs upon infection of mice with mutant virus mCMV-Δ4IDE during either acute or latent infection in the spleen [(57) and this report, respectively]. The gene discussed is CD8A; the disease is infection.