HAVCR2 and infection: Another murine model, this one with infection by Toxoplasma gondii, an intracellular parasite that induces a Th1-type response, identified that mice of the C57BL/6 strain (susceptible) have a lower frequency of TIM-3+ immune cells in the spleen and mesenteric lymphatic nodes (NK, CD3+, CD11b, and CD11c+) compared to resistant BALB/c mice (48).