HAVCR2 and neoplasm: Scientific evidence suggests that this phenotype, together with the increase in the expression of TIM-3, are induced by the TGF-β (41) and other cytokines, such as IL-4, IL-10, IL-13, and M-CSF found in the tumor microenvironment [reviewed by Allavena et al. (42)], which favor the alternative activation of macrophages.