HAVCR2 and infection: In an experimental model of in vitro infection with M.tb (H37Rv) performed in 2010, Jayaraman et al. demonstrated that when peritoneal macrophages were infected with M.tb (in the absence of T lymphocytes) and treated with TIM-3 in the form of a fusion protein, which is composed of the immunoglobulin V portion of mouse TIM-3 fused with the human IgG1 Fc tail to form the soluble TIM-3–Ig fusion protein, this protein limited bacterial growth through a mechanism that involved caspase-1-dependent IL-1b production (24).