For example, are Lewis rats tolerant to self-Hsp65?; how does activation of self-Hsp65-reactive T cells affect the development of arthritis?; how does immune response to foreign Hsp65 evolve during the course of AA?; what is the significance of the T cell repertoire against foreign Hsp65 that is cross-reactive with self-Hsp65?; what role do antibodies to Hsp65 play in AA?; and does Hsp65 treatment influence arthritis induced by a non-antigenic compound? Here, HSPD1 is linked to arthritic joint disease.