Recent literature on IL-36γ has been primarily focused on chronic inflammatory processes that include psoriasis and chronic obstructive pulmonary disease (COPD), where IL-36γ was found to be abundantly expressed in the skin and the mucosal ECs of the lung (Li et al., 2014; Gabay and Towne, 2015) and result in sustained inflammation (Chustz et al., 2011; Gabay and Towne, 2015). The gene discussed is IL36G; the disease is psoriasis.