PPARG and Miyoshi myopathy: Recent data have also found that the PPARγ agonist pioglitazone (PIO) enhances the cytotoxic effect of the histone deacetylase inhibitor (HDACi) and valproic acid (VPA) on MM cells, in vitro and in vivo, suggesting that agonizing PPARγ while inhibiting HDACs could decrease MM growth (83).