While early chromosomal abnormalities, such as immunoglobulin heavy chain translocations or trisomies, are present in both MGUS and MM, secondary translocations or mutations involving oncogenes (e.g., MMSET, MYC, MAFB, IRF4, FGFR3, RAS family members, among many others) (11) or tumor suppressors (e.g., CDKN2A, CDKN2C, or TP53) are unique to MM and absent in MGUS (12). The gene discussed is CDKN2A; the disease is Miyoshi myopathy.