NR3C2 and brain ischemia: Indeed, deletion of MR in mice was found to reduce granule cell neurogenesis (24) and to impair learning ability (25), whereas MR overexpression increased differentiation and survival of embryonic stem (ES) cell-derived neurons (26); furthermore, forebrain MR overexpression enhanced memory, reduced anxiety, and attenuated neuronal loss in mouse cerebral ischemia (27).