Although a role for glucocorticoids and GR has been suggested in the progression of AD (33), to date, the direct role of MR agonists on Aβ-induced toxicity has not been investigated and, based on the survival effects in neurons, it can be hypothesized an MR-induced protection against Aβ peptide-induced detrimental effects in hippocampal cells. This evidence concerns the gene NR3C2 and Alzheimer disease.