To date, about 16 single amino acid mutations in MYL2 have been linked to various forms of cardiomyopathy (Poetter et al., 1996; Flavigny et al., 1998; Andersen et al., 2001, 2009; Kabaeva et al., 2002; Richard et al., 2003; Olivotto et al., 2008; Garcia-Pavia et al., 2011; Claes et al., 2015; Huang et al., 2015). The gene discussed is MYL2; the disease is cardiomyopathy.