Other 59 different ATP1A3 de novo missense mutations are associated with AHC (Heinzen et al., 2014; Rosewich et al., 2014; Sasaki et al., 2014; Ulate-Campos et al., 2014; Yang et al., 2014; Panagiotakaki et al., 2015; Viollet et al., 2015). Here, ATP1A3 is linked to alternating hemiplegia of childhood.