Some ATP1A3-disease mutation related patients show additional neurological symptoms that range from mild limb cramping sometimes decades before developing RDP (Brashear et al., 2007) to dysfunction of the autonomic nervous system with cardiac repolarization problems (Novy et al., 2014; Jaffer et al., 2015) excessive or lack of perspiration, skin discoloration, gastrointestinal problems and changes in body temperature leading up to or during attacks in AHC patients (Mikati et al., 2000; Fons et al., 2012). This evidence concerns the gene ATP1A3 and dystonia 12.