Mutations in the ATP1A3 gene are associated with three related rare neurological disorders, Rapid-onset Dystonia-Parkinsonism (RDP) (de Carvalho Aguiar et al., 2004), Alternating Hemiplegia of Childhood (AHC) (Heinzen et al., 2012; Rosewich et al., 2012), and recently, Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss (CAPOS) syndrome (Demos et al., 2014). Here, ATP1A3 is linked to nervous system disorder.