IL4 and schistosomiasis: Schistosomiasis pathology results from an immune response against Schistosoma eggs and granulomatous inflammation around the deposited eggs, stimulated by soluble eggs antigen (SEA), mainly in the liver and intestine tissues (Hatz et al., 1998; Hams et al., 2013) SEA is known to stimulate an immune type 2 response (Th2) leading to the production of IL-4, IL-5, IL-13, and upregulation of immunoglobulin E (IgE) levels and eosinophils (Hams et al., 2013).