It is not clear what role TREM2 plays in amyloidogenic processes associated with prion infected human brain in Creutzfeldt-Jakob disease (CJD) or Gerstmann-Straussler-Scheinker (GSS), although markers of MG activation are down-regulated in prion-infected TREM2-/- mice suggesting TREM2 involvement in prion-induced MG-activation (Song et al., 2016; Ulrich and Holtzman, 2016). The gene discussed is TREM2; the disease is Creutzfeldt Jacob disease.