On the other hand significant TREM2 deficits have been reported during inflammatory neurodegeneration of the human CNS including sporadic AD and age-related macular degeneration (AMD; Zhao et al., 2013; Zhu et al., 2015; Bhattacharjee et al., 2016; Song et al., 2016). Here, TREM2 is linked to age-related macular degeneration.