RIMS1 and schizophrenia: Although CACNA1A (Cav2.1) and CACNA1B (Cav2.2) are not typically associated with risk loci, RIM1 (also called RIMS1)—a presynaptic scaffold that regulates density of P/Q- and N-type Ca2+ channels and SV docking at the active zone (Han et al., 2011)—was recently identified as a candidate gene for schizophrenia in the largest GWAS study conducted to date (Schizophrenia Working Group of the Psychiatric Genomics, 2014).