PLAU and preeclampsia: Indeed, uPA seems to play a role in trophoblast invasion and in the pathophysiology of preeclampsia (Strickland and Richards, 1992; Zhang et al., 1994; Uszynski and Uszynski, 2011), and may contribute to the increased risk of preeclampsia previously noted in SSRI users (Toh et al., 2009; De Vera and Berard, 2012; Palmsten et al., 2012, 2013).