Clinical evidence from developmental disorders that affect the CNS, including Lhermitte–Duclos disease (LDD), TSC, and neurofibromatosis type 1 (NF1) suggest that mTOR plays a key role in cell differentiation and growth control (Sandsmark et al., 2007; Crino, 2011). Here, MTOR is linked to Lhermitte-Duclos disease.