CACNA1A and epilepsy: Identifying this potential comorbidity may allow efforts to dissect the genetic basis of the condition to be targeted toward specific sets of genes that may have a role in both migraine and epilepsy pathophysiology, such as the ion channels enhancing excitatory neurotransmitter release (i.e., Cav2.1) or dendrite neuronal excitability and firing (Nav1.1), and their molecular interactors.