ATP1A2 and familial hemiplegic migraine: More than 30 FHM2 mutations have been identified (de Vries et al., 2009) and associated with pure disease (De Fusco et al., 2003; Riant et al., 2005; Vanmolkot et al., 2006), or with a combination of FHM and cerebellar ataxia (Spadaro et al., 2004), recurrent encephalopathy (Ducros et al., 2001; Spacey et al., 2005), impaired hearing and vertigo (Jurkat-Rott et al., 2004), or epilepsy (Roth et al., 2014).