PLAT and ischemic stroke: T-PA participates in axonal remodeling, neuronal plasticity, long-term potentiation (Seeds et al., 1995), propagation of excitotoxin-induced seizures (Qian et al., 1993; Tsirka et al., 1995; Endo et al., 1999; Wu et al., 2000; Yepes et al., 2002; Pawlak et al., 2005; Fredriksson et al., 2015), progression of cerebral infarct volume during ischemic stroke (Wang et al., 1998; Kano et al., 2000; Yepes et al., 2000), and regulation of blood brain barrier permeability in a number of pathologic conditions (Yepes et al., 2003; Su et al., 2008; Fredriksson et al., 2015; Lewandowski et al., 2016).