The WNK kinases are a family of serine/threonine kinases that are expressed in the mammalian kidney, and mutations in them can cause Gordon's syndrome ( http://omim.org/entry/145260), also known as pseudohypoaldosteronism type 2 (PHA2) or Familial Hyperkalemic Hypertension (FHHt). The gene discussed is MARK2; the disease is pseudohypoaldosteronism type 2.