2008, 2011; Delpire and Gagnon 2008) and hence hypertension due to the salt retention. Subjects with FHHt also have abnormalities in other electrolyte flux pathways showing typically hyperkalemia and metabolic acidosis, that is only partly driven by NCC activation (McCormick et al. 2014; Boyden et al. 2012; Glover et al. 2014; Osawa et al. 2013; Tsuji et al. 2013). Here, SLC12A3 is linked to hypertensive disorder.