UNC5B and breast cancer: For example, UNC5B, while unmethylated, was upregulated in DAC‐treated MDA‐MB‐231 cells, and it was previously shown that in breast cancer cells, the downregulation of some methylated genes is dependent on the deposition of the methyl‐CpG binding domain protein 2 (MBD2) within their promoter sequence (Devailly et al, 2015).