MTOR and Alzheimer disease: Consistent with our finding, strong published evidence indicates that alterations in protein translation may contribute to the pathogenesis of AD.31 We, and others, have previously shown that the mammalian target of rapamycin, a master regulator of protein translation,32 is upregulated in human AD brains.18, 33, 34, 35 These alterations in protein translation may lead to the changes of proteins involved in AD pathogenesis and learning and memory.