Within the last decades, several mouse and also rat models have been established for familial AD (FAD), mainly based on the three genes that are involved in development of the subtype of the disease: single transgenic mice with either mutations in APP (amyloid precursor protein) or one of the presenilins (PS1 or 2) reveal some of the disease criteria such as plaque deposition or memory deficits. Here, APP is linked to familial Alzheimer disease.