This possibility is supported further when we observe T cells low for the PD1 were predictive of positive outcome, and indeed the synergistic (or network) outcome of the PD1-low cells relative to immunosuppressive T regulatory cells revealed a highly predictive response to the chemotherapy: suggestive that the tumor infiltrating CD8+ T cells were not subject to PD1-PDL1 inhibitory signals, in patients with positive outcome, and therefore may have the capacity to mount an immune attack. Here, CD8A is linked to neoplasm.