The NK cell gene signatures were not reported from these metastatic melanomas patients previously, but corresponds well with the emerging knowledge of NK cell interactions with melanomas [45]., The most significant DIST signature was that of a predicted B cell infiltrate associated to positive clinical outcome, for a CD19+ B cell phenotype [43], and corresponds with the emerging knowledge of the role of regulatory B cells in the immune pathology of a tumor [44]. This evidence concerns the gene CD19 and neoplasm.