BRAF and melanoma: The larger presence of CD8+ cytotoxic T cells and Th1 cells in BRAFV600 metastatic melanomas once again suggests the presence of a potential tumor-killing environment, recruited to the tumor as a result of the BRAF oncogenic insult, but suppressed due to many possible immune-escape mechanisms including that of the high T-helper 2 ratio dominant in the BRAFV600 patient network, as opposed to the low CD8+ and T-helper 1 positive cells in the NRAS patients (Fig. 4a).