The role of family history, germinal mutation of BRCA1/2 genes, risk of cancers associated to breast and ovarian cancer syndrome related to BRCA1/2 genes, suggest that cancer genetic counseling for MBC patients should contribute to better clarify genotype-phenotype correlations and to personalize surveillance strategies according to international guidelines (http://www.nccn.org/professionals/physician_gls/f_guidelines_nojava.asp#site). This evidence concerns the gene BRCA1 and cancer.