ASPG and pancreatitis: On the basis of the previously documented protective effects of Ca2+ entry channel inhibition against alcohol-related pancreatic pathology in isolated cell clusters [9,38], the recent confirmation of its effectiveness in vivo in three different mouse pancreatitis models [43] and the very recently demonstrated inhibition of prolonged Ca2+ signal generation in pancreatic stellate cells [31,32], our new data indicate that this therapeutic approach is also likely to be successful against asparaginase-induced pancreatitis.