Strikingly, Nod2 genetic depletion induced a three-fold reduction (P < 0.05) in the phosphorylation of JNK1/2 (Fig. 5D), p38 (Fig. 5E) and ERK (Fig. 5F) of peritoneal cells obtained from mice under LD100 infection (Representative dot plots in Fig. S3). This evidence concerns the gene MAPK8 and infection.