In fact, when MPGC‐1α TGs were fed HFD they developed insulin resistance and were not protected from diet‐induced obesity, showing increased lipid uptake and lipogenesis genes in skeletal muscle, including Cd36, and no change in resting serum insulin, triglycerides, cholesterol, glucose, and FFAs 29. This evidence concerns the gene CD36 and obesity due to melanocortin 4 receptor deficiency.