As shown in Fig. 3, CD80 mRNA levels were inversely correlated with the DNMT3A mRNA levels in healthy colonic mucosa of patients with adenoma and with DNMT3B in healthy colonic mucosa of patients with cancer (τ = −0.44, p = 0.07 and τ = −0.50, p = 0.04, respectively). This evidence concerns the gene DNMT3A and cancer.