As shown in Fig. 3, CD80 mRNA levels were inversely correlated with the DNMT3A mRNA levels in healthy colonic mucosa of patients with adenoma and with DNMT3B in healthy colonic mucosa of patients with cancer (τ = −0.44, p = 0.07 and τ = −0.50, p = 0.04, respectively). Here, CD80 is linked to cancer.