To assess the impact of PTX3 overexpression on the tumorigenesis of cervical cancer cells in vivo. The results of these experiments indicated that the tumor significantly larger in the xenografts of Rh-PTX3-SiHa cells than those in the xenografts of control cells at 16 days (Fig. 7a,b), and it significantly increased the tumor weight (Fig. 7c) and the expression of Ki-67 than those in the xenografts of control cells (Fig. 7e), whereas no was observed in different in body weight between the xenografts of control cells and Rh-PTX3-treated SiHa cells mice (Fig. 7d). The gene discussed is MKI67; the disease is cervical carcinoma.