Bonavita et al. demonstrated that PTX3-deficient mice treated with 7,12-dimethylbenz [α] anthracene/terephthalic acid or 3-methylcholantrene had an increase in the formation of sarcomas and an increase in the incidence and multiplicity of papillomas and skin carcinomas, it correlation with cancer-related inflammation, such as CCL2 and C5a production. Here, CCL2 is linked to papilloma.