A targeted toxin consisting of vascular endothelial growth factor and mutated staphylococcal enterotoxin A was used to attract cytotoxic T lymphocytes, which then secreted perforin and granzyme B (abbreviated as GzmB, Gb or GrB) around the tumor resulting in granzyme B-mediated death of tumor cells supported by perforins [120]. Here, PRF1 is linked to neoplasm.