NLRP3 and cardiovascular disorder: Several studies indicated the correlation between IL-17A and CRP in different diseases, such as cardiovascular disease [22], inflammatory bowel disease [23], Cystic Echinococcosis [24], Behcet’s disease [25], etc. It was also reported that IL-17A triggered the inflammatory mediator Interleukin-1α (IL-1α) through NLR family pyrin domain containing 3 (NLRP3) inflammasome and NF-κB signal [26].