Another study performed by Kim et al. [73] using MEFs to study the role of Makorin Ring Finger Protein 1 (MKRN1), which is a negative regulator of PPAR-γ2 in obesity, indicated that MKRN1 is a potential new therapeutic target in PPAR-γ related diseases. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.