There were significant post-intervention changes for weight (>10% loss), fruit and vegetable consumption (+3.7 ± 4.3 servings/day), and physical activity (+1235 ± 832 kcal/week), and reductions in two biochemical mediators of breast cancer risk, fasting insulin (−16.7%) and leptin (−37.1%). The gene discussed is LEP; the disease is breast cancer.