Few examples include PPARG mutation in familial partial lipodystrophy (FPLD3)[18], INSR in Donahue syndrome and Type A insulin resistance, HNF4A in Maturity-Onset Diabetes of Young (MODY1) [19,20], and INS in Diabetes-type hyperglycemia and hyperinsulinemia [19,21]. The gene discussed is INSR; the disease is diabetes mellitus.