Genome-wide linkage analysis and exome sequencing together, recently, led to the discovery of a novel TGFB3 mutation as a cause of syndromic aortic aneurysm and aortic dissection in series of 470 index cases with thoracic aortic aneurysms who had been screened for all known gene mutations associated with thoracic aortic aneurysms (35). The gene discussed is TGFB3; the disease is Aortic dissection.