IL4 and allergic disease: In this regard, TH2 cell-derived cytokines such as IL-4, IL-5, and IL-13 play a critical role in the pathogenesis of allergic reaction (Brandt and Sivaprasad, 2011); IL-4 and IL-13 stimulate IgE production, and IL-5 is responsible for eosinophil growth, differentiation, migration, activation, and survival (Del Prete, 1998).