IGF1 and breast cancer: In the European group, the minor A-allele of three IGF1 SNPs (rs1549593, rs1019731, and rs12821878) was associated with decreased risk of breast cancer, but only two of these SNPs passed adjustment for the FDR: rs1019731 (OR = 0.67, 95% CI: 0.53–0.84) and rs12821878 (OR = 0.73, 95% CI: 0.61–0.88).