The cumulative ovarian cancer risk by age 70 (including fallopian tube and primary peritoneal carcinomas) is 40% for BRCA1 and 20% for BRCA2 mutation carriers respectively (Antoniou et al., 2003; Chen & Parmigiani, 2007; King, Marks & Mandell, 2003). The gene discussed is BRCA1; the disease is ovarian carcinoma.