Similarly, this analysis reports a marked and sustained reduction in BMI for obese patients with T1D after bariatric surgery (weighted mean difference of 13.42 at study endpoint, P < 0.00001) that is accompanied by a reduction in total daily insulin requirement (weighted mean difference of 49.98 IU/d at study endpoint, P < 0.00001). Here, INS is linked to type 1 diabetes mellitus.