High and early postprandial hyperglycemic peaks followed by rapid interstitial glucose decreases are observed after RYGB, which may account for the hypoglycemic-like symptoms that have been previously reported in patients with T2D after bariatric surgery [15, 22, 29] and, in the T1D population, can contribute to a mismatch between blood glucose and subcutaneous insulin administration. This evidence concerns the gene INS and type 1 diabetes mellitus.