For instance, thioredoxin reductase, thioredoxin, peroxiredoxin, glutathione S-transferase pi 1, glucose-6-phosphate dehydrogenase, and apurinic/apyrimidinic endonuclease 1/ref-1 (APE1/ref-1) have been found to be increased, while glutamate-cysteine ligase and γ-glutamyltransferase have been found to be decreased in lung cancer cells [6, 7]. The gene discussed is APEX1; the disease is lung carcinoma.