Although conventional treatments for DN dual blockade strategies have lowered the risk of albuminuria [4], angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are not able to prevent the development of albuminuria in normotensive individuals with type 2 diabetes mellitus (T2DM) [5, 6]. This evidence concerns the gene ACE and type 2 diabetes mellitus.