In addition, miR-145 may be detected in serum samples from cancer and normal patients31 miR-145 re-expression in breast cancer was accompanied by a “pro-apoptotic effect, dependent on TP53 activation”, while TP 53 can, in turn provoke miR-145 expression, thus forming a death promoting link among miR-145 and TP53. Here, TP53 is linked to breast cancer.