Liang et al. explained in detail some of the miRs that are involved in drug resistance, which include miR-326,40 miR-328 and miR-34a.39 It is determined that miR-31a is a straight target of p53,31 “miR-21 overexpression is associated with the development and progression of multidrug resistance in breast cancer” and hopefully also rising as an original and optimistic reversing target.31,40. Here, TP53 is linked to breast carcinoma.