Examples of such miRs are “miR-18a, miR-22, miR-181, miR-206, miR-221/222” that have proven to be a part in downregulation of Estrogen Receptor-α expression and in suppression of ER-α-mediated motioning in breast carcinoma cell lines.33 By adapting the signatures of these miRs, it is probable to find a novel way of remedy for ER-α-negative breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.