ALB and Increased total leukocyte count: Compared with AAD patients, CDAD patients usually present more severe clinical manifestations and have more concurrent illnesses.17 Laboratory markers, such as leukocytosis, increased creatinine levels, and decreased albumin levels, were reported to correlate with the development and poor outcome for patients with CDAD.18 Disrupting normal intestinal flora by antibiotics is a well-known mechanism for CDAD.