Score model is optimized for European clinical practice, Swiss society of cardiology recommended that absolute CVD risk score subsequently requires the multiplication by factor of 1.5, while EULAR contrary to above has advised the multiplication factor use when RA disease more than 10-years duration, RF or ACPA positivity, presence of certain extra articular features.13,14 Recently NICE has validated the QRISK-2 risk calculator for cardiovascular risk screening.15,16. The gene discussed is PRTN3; the disease is rheumatoid arthritis.