BMDC required IL-10 but not IDO (indoleamine 2, 3-dioxygenase) to switch to a regulatory phenotype as IgM + LPS pretreatment of IL-10 ko BMDC, but not IDO ko BMDC, failed to protect mice from developing AKI after renal ischemia (4). The gene discussed is CD40LG; the disease is acute kidney injury.