CD40LG and diabetes mellitus: Additionally, in murine models, we showed that increasing in vivo levels of IgM-ALA with physiological doses of purified polyclonal IgM, i.e., 150 μg/mouse, every 3 days, protected mice from (a) renal ischemia reperfusion injury (IRI), (b) ameliorated rejection in a fully mis-matched cardiac allograft model, and (c) protected NOD mice from developing autoimmune insulitis and diabetes.