PLOD1 and polycystic ovary syndrome: Dysregulation and reprograming of the hypothalamus–pituitary–ovarian (HPO) axis is common in PCOS, potentially driven by androgen exposure in utero and manifesting as hypersecretion of LH, persistently rapid LH pulse frequency, and below-normal levels of follicle-stimulating hormone (FSH) (82, 83).