In conclusion, this study demonstrated for the first time that CIHH protects the heart against I/R injury through improvement of the energy metabolism via upregulating cardiac GLUT4, p-AMPK, and PGC-1α expressions and downregulating cardiac PDK4 expression, which will provide a new concept or strategy for prevention and treatment of ischemic heart disease. The gene discussed is PRKAA1; the disease is coronary artery disorder.