Both asthma and COPD are inflammatory disorders, but their inflammatory patterns differ: the mast-cell/CD4+ T cells/eosinophils axis prevails in asthma, whereas neutrophils/CD8+ T cells (Barnes, 2008) and premature lung senescence (Chilosi et al., 2013) associated to the activation of the receptors of advanced glycation end-products (RAGE; Robinson et al., 2012) fuel COPD. Here, CD4 is linked to chronic obstructive pulmonary disease.