CCDC80 and pulmonary arterial hypertension: Ccdc80 was not readily detected in the PAs of control rats (Figures 5A,E), but there was intense immunoreactivity in the hypertrophied media and adventitia of the pre-acinar PAs (Figure 5B) and in the thickened intima, media, and adventitia of the obstructed intra-acinar PAs (Figure 5F) in the PAH rat.